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Inflamm Res. 2008 Jun;57(6):279-86. doi: 10.1007/s00011-007-7077-3.

Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children.

Author information

1
Paediatric Department, Albert Szent-Györgyi Medical and Pharmaceutical Centre, University of Szeged, Korányi fasor 14-15, Szeged 6725, Hungary. bedeolga@freemail.hu

Abstract

OBJECTIVE:

Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4-16 years in a randomized, double-blind, placebo-controlled study.

DESIGN:

Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed.

RESULT:

The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study.

CONCLUSION:

Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

PMID:
18516713
DOI:
10.1007/s00011-007-7077-3
[Indexed for MEDLINE]

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