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Sleep Breath. 2008 Nov;12(4):397-9. doi: 10.1007/s11325-008-0192-8. Epub 2008 May 31.

Predictors of fatigue in obstructive sleep apnea.

Author information

1
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. pmills@ucsd.edu

Abstract

OBJECTIVE:

The objective of this study was to determine potential inflammatory predictors of fatigue in obstructive sleep apnea (OSA).

MATERIALS AND METHODS:

Fifty-six women and men untreated OSA patients had their sleep monitored with polysomnography. Fatigue was assessed by the Multidimensional Fatigue Symptom Inventory-Short Form. Depressed mood was assessed by the Center for Epidemiologic Studies-Depression Scale. Blood was drawn to assess circulating levels of Interleukin-6 (IL-6) and soluble tumor necrosis factor receptor I (sTNF-RI). Age, gender, body mass index (BMI), blood pressure, OSA severity, depressed mood, and inflammatory biomarkers were entered into a hierarchical multiple linear regression analysis predicting self-reported fatigue.

RESULTS:

Approximately 42% of the patients reported significant amounts of fatigue. Higher BMI (p = 0.014), greater depressed mood (p = 0.004), and higher sTNF-RI levels (p = 0.033) were independent predictors of fatigue in the final model (full model R2 = .571; p = .003). Age, gender, blood pressure and apnea severity were unrelated to fatigue.

CONCLUSION:

The findings suggest that in addition to depressed mood, fatigue in OSA may be associated with increased body weight and elevated levels of the proinflammatory cytokine receptor sTNF-RI. The findings support a linkage between the widely reported fatigue in OSA and a sleep-related component of inflammation.

PMID:
18516635
PMCID:
PMC2633300
DOI:
10.1007/s11325-008-0192-8
[Indexed for MEDLINE]
Free PMC Article

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