Format

Send to

Choose Destination
Nat Neurosci. 2008 Jul;11(7):744-5. doi: 10.1038/nn.2125. Epub 2008 May 30.

Spike timing-dependent long-term depression requires presynaptic NMDA receptors.

Author information

1
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. arodmor@upo.es

Abstract

NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.

PMID:
18516036
DOI:
10.1038/nn.2125
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center