Format

Send to

Choose Destination
See comment in PubMed Commons below
Reproduction. 2008 Sep;136(3):295-301. doi: 10.1530/REP-08-0091. Epub 2008 May 30.

Kisspeptin and KISS1R: a critical pathway in the reproductive system.

Author information

1
Reproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, BHX 5, Boston, Massachusetts 02114, USA. egianetti@partners.org

Abstract

In 2003, three groups around the world simultaneously discovered that KISS1R (GPR54) is a key gatekeeper of sexual maturation in both mice and men. Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of GNRH-induced gonadotropin secretion and may modulate both positive and negative sex steroid feedback effects at the hypothalamic level. Genetic studies in humans have revealed both loss-of-function and gainof-function mutations in patients with idiopathic hypogonadotropic hypogonadism and precocious puberty respectively. This review examines the kisspeptin/KISS1R pathway in the reproductive system.

PMID:
18515314
PMCID:
PMC2858313
DOI:
10.1530/REP-08-0091
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center