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Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):860-6. doi: 10.1016/j.bbabio.2008.05.442. Epub 2008 May 26.

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy.

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1
Dulbecco-Telethon INStitute, Venetian INStitute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.

Abstract

Damaged mitochondria can be eliminated in a process of organelle autophagy, termed mitophagy. In most cells, the organization of mitochondria in a network could interfere with the selective elimination of damaged ones. In principle, fission of this network should precede mitophagy; but it is unclear whether it is per se a trigger of autophagy. The pro-fission mitochondrial protein Fis1 induced mitochondrial fragmentation and enhanced the formation of autophagosomes which could enclose mitochondria. These changes correlated with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fis1 mutants with different effects on organelle shape and function. In conclusion, fission associated with mitochondrial dysfunction stimulates an increase in autophagy.

PMID:
18515060
DOI:
10.1016/j.bbabio.2008.05.442
[Indexed for MEDLINE]
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