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Trends Genet. 2008 Jul;24(7):336-43. doi: 10.1016/j.tig.2008.04.007.

Sex chromosomes and speciation in Drosophila.

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  • 1Department of Biology, University of Rochester, Rochester, NY 14627, USA. dvnp@mail.rochester.edu <dvnp@mail.rochester.edu>

Abstract

Two empirical rules suggest that sex chromosomes play a special role in speciation. The first is Haldane's rule - the preferential sterility and inviability of species hybrids of the heterogametic (XY) sex. The second is the disproportionately large effect of the X chromosome in genetic analyses of hybrid sterility. Whereas the causes of Haldane's rule are well established, the causes of the 'large X-effect' have remained controversial. New genetic analyses in Drosophila confirm that the X is a hotspot for hybrid male sterility factors, providing a proximate explanation for the large X-effect. Several other new findings -- on faster X evolution, X chromosome meiotic drive and the regulation of the X chromosome in the male-germline -- provide plausible evolutionary explanations for the large X-effect.

PMID:
18514967
PMCID:
PMC2819171
DOI:
10.1016/j.tig.2008.04.007
[PubMed - indexed for MEDLINE]
Free PMC Article
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