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Trends Genet. 2008 Jul;24(7):323-7. doi: 10.1016/j.tig.2008.04.004. Epub 2008 May 29.

MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control.

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1
Bioinformatics Research Group, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.

Abstract

Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (mlRNAs). To investigate whether mlRNAs are subject to miRNA control, we compared the expression of mlRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mlRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control.

PMID:
18514357
DOI:
10.1016/j.tig.2008.04.004
[Indexed for MEDLINE]
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