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Fungal Genet Biol. 2008 Aug;45 Suppl 1:S54-62. doi: 10.1016/j.fgb.2008.04.009. Epub 2008 May 29.

Predicted elements of telomere organization and function in Ustilago maydis.

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  • 1Centro de Investigaciones Microbiológicas, Instituto de Ciencias, BUAP Av. San Claudio y 18 sur, Edif. 76 3er piso, C.U. Puebla, Pue. 72570, Mexico.

Abstract

Telomeres are specialized caps of nucleoprotein complexes located at the chromosome termini. They consist of short DNA repeats and of an assortment of associated proteins whose function is currently under intense investigation in model systems. These specialized structures protect the linear ends of eukaryotic chromosomes against DNA repair and degradation activities, and serve as the substrate for telomerase, the ribonucleoprotein complex that synthesises the telomere repeats. The pivotal role of the telomeres in the maintenance of cell viability in several model eukaryotes, including humans, greatly promoted research in telomere biology. Studies on telomere structure and function in fungi other than model systems are limited to providing information on the telomeric repeat sequences. Here, we have summarized the current knowledge on the organization of chromosome ends and on the proteins participating in telomere function in model systems including recent information obtained for filamentous fungi. We also describe Ustilago maydis genes that are potential homologs of proteins known from other systems to participate in telomere biology.

PMID:
18514000
DOI:
10.1016/j.fgb.2008.04.009
[PubMed - indexed for MEDLINE]
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