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J Am Chem Soc. 2008 Jun 25;130(25):7782-3. doi: 10.1021/ja801755z. Epub 2008 May 31.

Cooperative catalysis with chiral Brønsted acid-Rh2(OAc)4: highly enantioselective three-component reactions of diazo compounds with alcohols and imines.

Author information

1
Department of Chemistry, East China Normal University, Shanghai 200062, China. whu@chem.ecnu.edu.cn

Abstract

An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid provides a general and efficient entry to beta-amino-alpha-hydroxyl acid derivatives in high yields with excellent stereoselectivities.

PMID:
18512907
DOI:
10.1021/ja801755z

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