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Antimicrob Agents Chemother. 1991 Feb;35(2):387-9.

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

Author information

1
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, United Kingdom.

Abstract

Seven nalidixic acid-resistant clinical isolates of Escherichia coli were shown to carry resistance mutations in their gyrase A proteins. Six had serine-83 to leucine or tryptophan changes; the seventh had an aspartate-87 to valine substitution. The frequent occurrence of a mutation at serine-83 implies a key role for this residue in quinolone action.

PMID:
1850972
PMCID:
PMC245014
[Indexed for MEDLINE]
Free PMC Article

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