Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Neurol. 2008 Jul;64(1):53-9. doi: 10.1002/ana.21403.

Ambient air pollution and risk for ischemic stroke and transient ischemic attack.

Author information

1
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109-2029, USA. llisabet@umich.edu

Abstract

OBJECTIVE:

Data on the association between air pollution and cerebrovascular disease in the United States are limited. The objective of this study was to investigate the association between short-term exposure to ambient air pollution and risk for ischemic cerebrovascular events in a US community.

METHODS:

Daily counts of ischemic strokes/transient ischemic attacks (TIAs) (2001-2005) were obtained from the population-based Brain Attack Surveillance in Corpus Christi (BASIC) Project. Daily particulate matter less than 2.5microm in diameter (PM(2.5)), ozone (O(3)), and meteorological data were obtained from Texas Commission on Environmental Quality. To examine the association between PM(2.5) and stroke/TIA risk, we used Poisson regression. Separate models included same-day PM(2.5), PM(2.5) lagged 1 to 5 days, and an averaged lag effect. All models were adjusted for temperature, day of week, and temporal trends in stroke/TIA. The effects of O(3) were also investigated.

RESULTS:

Median PM(2.5) was 7.0microg/m(3) (interquartile range, 4.8-10.0microg/m(3)). There were borderline significant associations between same-day (relative risk [RR], 1.03; 95% confidence interval [CI], 0.99-1.07 for an interquartile range increase in PM(2.5)) and previous-day (RR, 1.03; 95% CI, 1.00-1.07) PM(2.5) and stroke/TIA risk. These associations were independent of O(3), which demonstrated similar associations with stroke/TIA risk (same-day RR, 1.02; 95% CI, 0.97-1.08; previous-day RR, 1.04; 95% CI, 0.99-1.09).

INTERPRETATION:

We observed associations between recent PM(2.5) and O(3) exposure and ischemic stroke/TIA risk even in this community with relatively low pollutant levels. This study provides data on environmental exposures and stroke risk in the United States, and suggests future research on ambient air pollution and stroke is warranted.

PMID:
18508356
PMCID:
PMC2788298
DOI:
10.1002/ana.21403
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center