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J Clin Psychiatry. 2008 Apr;69(4):e11.

Relapse prevention in patients with schizophrenia.

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  • 1Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.


Remission is a realistic goal for patients with schizophrenia, and, if sustained remission can be achieved, then patients may eventually attain functional recovery. The chance of relapse is decreased if patients are adherent to their pharmacotherapeutic treatment regimen. This case explores how to prevent relapse for a patient with schizophrenia and comorbid substance use disorder who is nonadherent to an oral atypical antipsychotic. To help the patient achieve treatment goals, intervention strategies such as switching medications and implementing psychosocial therapies are considered.

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