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Anticancer Res. 2008 Mar-Apr;28(2A):907-11.

miR-21 microRNA expression in human gastric carcinomas and its clinical association.

Author information

1
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Republic of China.

Abstract

BACKGROUND:

MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been shown to be aberrantly expressed in many human carcinomas. Of these miRNAs, miR-21 appears to be important in tumorigenesis given its up-regulation in almost all types of human cancer examined. However, its association with the clinicopathological features of human gastric cancer has yet to be addressed.

PATIENTS AND METHODS:

Cancer tissues and corresponding normal tissues from 37 patients with gastric cancer were examined for the expression level of miR-21 using quantitative PCR and the clinical relevance of miR-21 was statistically analyzed.

RESULTS:

miR-21 was overexpressed in 92% (34/37) of the gastric cancer samples examined. However, the patients with higher miR-21 expression did not have a worse prognosis.

CONCLUSION:

miR-21 could serve as an efficient diagnostic marker for gastric cancer, but does not affect the clinical prognosis of gastric cancer patients.

PMID:
18507035
[Indexed for MEDLINE]
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