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Schizophr Res. 2008 Jul;102(1-3):181-8. doi: 10.1016/j.schres.2008.04.019. Epub 2008 May 27.

Age-related deficits in fronto-temporal connections in schizophrenia: a diffusion tensor imaging study.

Author information

  • 1Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, United States.

Abstract

OBJECTIVE:

Impairment of white matter connecting frontal and temporal cortices has been reported in schizophrenia. Yet, not much is known about the effects of age on fibers connecting these brain regions. Using diffusion tensor imaging tractography, we investigated the relationship between age and fiber integrity in patients with schizophrenia vs. healthy adults.

METHODS:

DTI tractography was used to create 3D reconstructions of the cingulum, uncinate and inferior occipito-frontal fasciculi in 27 patients with schizophrenia and 34 healthy volunteers (23-56 years of age, group-matched on age). Fractional anisotropy (FA), describing fiber integrity, was then calculated along the entire length of these tracts, and correlated with subjects' age.

RESULTS:

Patients revealed a significant decline in FA with age in both the cingulum and uncinate, but not in the inferior occipito-frontal fasciculi. No statistically significant correlations were found in these fiber bundles in controls.

CONCLUSIONS:

These results suggest an age-associated reduction of frontal-temporal connectivity in schizophrenia, but not in healthy controls.

PMID:
18504117
PMCID:
PMC2684860
DOI:
10.1016/j.schres.2008.04.019
[PubMed - indexed for MEDLINE]
Free PMC Article
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