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FEBS Lett. 2008 Jun 25;582(15):2257-62. doi: 10.1016/j.febslet.2008.05.021. Epub 2008 May 27.

TRPV1-null mice are protected from diet-induced obesity.

Author information

1
Department of Pharmacology, Georgetown University, 3900 Reservoir Road NW, Washington, DC 20007, USA.

Abstract

We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild-type and TRPV1-null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1-null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild-type and TRPV1-null mice were approximately 51 and 34g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1-null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3-L1 preadipocytes expressed functional calcitonin gene-related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism.

PMID:
18503767
PMCID:
PMC2486372
DOI:
10.1016/j.febslet.2008.05.021
[Indexed for MEDLINE]
Free PMC Article

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