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Int J Cosmet Sci. 2000 Jun;22(3):201-6. doi: 10.1046/j.1467-2494.2000.00045.x.

Topical formulation of a new plant extract complex with refirming properties. Clinical and non-invasive evaluation in a double-blind trial.

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Department of Dermatology, IRCCS Policlinico S. Matteo, Università di Pavia, 27100 Pavia, Italy.


We tested an OTC formulation versus placebo in a double-blind trial to evaluate its ability to improve elasticity and firmness of the skin. The clinical non-invasive evaluation in 20 volunteers shows: 1. No adverse reactions such as itching or irritation 2. Efficacy and cosmetic acceptibility of the test cream 3. An increase in electrical capacitance (moisture content) even though without statistical significance. This result is not surprising because the patients had healthy skin and were relatively young (aged 20-25) 4. A very significant improvement in the biomechanical properties (extensibility and firmness) of the skin. This increase was statistically significant (P < 0.02) The main components of the cream (boswellic acids, Sylibin and Centella asiatica extracts) were formulated as complexes with lyso-phospholipids and soya bean non-saponifiable lipids.

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