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Org Lett. 2008 Jun 19;10(12):2581-4. doi: 10.1021/ol800856e. Epub 2008 May 27.

Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.

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  • 1Department of Chemistry, Shahid Beheshti University, Tehran, Iran.


A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.

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