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J Antibiot (Tokyo). 2008 Apr;61(4):245-9. doi: 10.1038/ja.2008.36.

Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.

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1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.

Abstract

Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.

PMID:
18503205
DOI:
10.1038/ja.2008.36
[Indexed for MEDLINE]
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