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Pediatr Clin North Am. 2008 Jun;55(3):735-55, xii. doi: 10.1016/j.pcl.2008.02.017.

Pharmacokinetics and pharmacodynamics in the critically ill child.

Author information

1
The Children's Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Boulevard, Suite 916 H, Philadelphia, PA 19104, USA. zuppa@email.chop.edu

Abstract

An understanding of pharmacokinetics and pharmacodynamics can allow for a rational approach to prescribing medications for critically ill children. Absorption, distribution, metabolism, elimination, and the response to medications are affected by age and disease state. Various medications are used in the care of critically ill children. Many medications are prescribed for children based on dosing guidance from adult studies, however. Care providers must be cautious of the high risk for drug interactions and adverse reactions in the intensive care setting.

PMID:
18501763
DOI:
10.1016/j.pcl.2008.02.017
[Indexed for MEDLINE]

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