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Trends Plant Sci. 2008 Jun;13(6):295-302. doi: 10.1016/j.tplants.2008.04.006. Epub 2008 May 22.

Multiple roles for protein palmitoylation in plants.

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School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK.


Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.

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