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Transfus Clin Biol. 2008 Feb-Mar;15(1-2):14-8. doi: 10.1016/j.tracli.2008.03.011. Epub 2008 May 23.

Adhesion of sickle red cells to endothelium: myths and future directions.

Author information

1
Department of Medicine, University of Minnesota, MMC 480, 420 Delaware Street S.E., Minneapolis, MN 55455, USA. hebbe001@umn.edu

Abstract

Sickle RBC are abnormally adherent to vascular endothelial cells. We briefly review the mechanisms that underlie this type of cell/cell adhesion, expose a number of extant myths about RBC adhesion, and discuss some aspects that need consideration via future experimentation. The relationship of this phenomenon of RBC-endothelial adhesion to the cytoadherence of parasitized sickle RBC is not yet clear.

PMID:
18501652
DOI:
10.1016/j.tracli.2008.03.011
[Indexed for MEDLINE]

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