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Nat Immunol. 2008 Jul;9(7):810-9. doi: 10.1038/ni.1617. Epub 2008 May 25.

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.

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1
Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

Abstract

Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.

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PMID:
18500345
DOI:
10.1038/ni.1617
[Indexed for MEDLINE]
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