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Nat Rev Cancer. 2008 Jun;8(6):438-49. doi: 10.1038/nrc2396.

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

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1
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

Abstract

The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is regulated by phosphorylation--through the activity of cyclin-dependent kinases (CDKs)--and protein degradation, which occurs through ubiquitin ligases such as SCF (SKP1-CUL1-F-box protein) complexes and APC/C (anaphase-promoting complex/cyclosome). Here, we explore the functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and beta-TrCP (beta-transducin repeat-containing protein), which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates.

PMID:
18500245
PMCID:
PMC2711846
DOI:
10.1038/nrc2396
[Indexed for MEDLINE]
Free PMC Article

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