Format

Send to

Choose Destination
Nat Rev Immunol. 2008 Jun;8(6):467-77. doi: 10.1038/nri2326.

Inhibitory B7-family molecules in the tumour microenvironment.

Author information

1
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA. wzou@med.umich.edu

Abstract

The B7 family consists of activating and inhibitory co-stimulatory molecules that positively and negatively regulate immune responses. Recent studies have shown that human and rodent cancer cells, and stromal cells and immune cells in the cancer microenvironment upregulate expression of inhibitory B7 molecules and that these contribute to tumour immune evasion. In this Review, we focus on the roles of these B7 molecules in the dynamic interactions between tumours and the host immune system, including their expression, regulation and function in the tumour microenvironment. We also discuss novel therapeutic strategies that target these inhibitory B7 molecules and their signalling pathways to treat human cancer.

PMID:
18500231
DOI:
10.1038/nri2326
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center