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Eur J Cell Biol. 2008 Sep;87(8-9):649-67. doi: 10.1016/j.ejcb.2008.04.001. Epub 2008 May 21.

Ins and outs of ADF/cofilin activity and regulation.

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Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium.


The actin-binding proteins of the actin-depolymerisation factor (ADF)/cofilin family were first described more than three decades ago, but research on these proteins still occupies a front role in the actin and cell migration field. Moreover, cofilin activity is implicated in the malignant, invasive properties of cancer cells. The effects of ADF/cofilins on actin dynamics are diverse and their regulation is complex. In stimulated cells, multiple signalling pathways can be initiated resulting in different activation/deactivation switches that control ADF/cofilin activity. The output of this entire regulatory system, in combination with spatial and temporal segregation of the activation mechanisms, underlies the contribution of ADF/cofilins to various cell migration/invasion phenotypes. In this framework, we describe current views on how ADF/cofilins function in migrating and invading cells.

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