Abstract
This study was designed to examine the impact of a principal component of hot red peppers and chilli peppers, capsaicin, on alterations in lipid peroxidation, membrane-bound enzyme profiles and glycoprotein levels during benzo(a)pyrene (BP)-induced lung cancer in Swiss albino mice. BP (50 mgkg(-1)) induced deleterious changes that were that revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K+ ATPase, Ca2+ ATPase and Mg2+ ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose). Pre-co-treatment with capsaicin (10 mg kg(-1)) restored the detrimental effects induced by BP, indicating its protective role in BP-induced lung cancer.
MeSH terms
-
Animals
-
Anticarcinogenic Agents / pharmacology*
-
Benzo(a)pyrene / toxicity
-
Ca(2+) Mg(2+)-ATPase / drug effects
-
Ca(2+) Mg(2+)-ATPase / metabolism
-
Calcium-Transporting ATPases / drug effects
-
Calcium-Transporting ATPases / metabolism
-
Capsaicin / pharmacology*
-
Carcinogens / toxicity
-
Cell Membrane / drug effects*
-
Cell Membrane / enzymology
-
Glycoproteins / drug effects
-
Glycoproteins / metabolism
-
Lipid Peroxidation / drug effects
-
Lung Neoplasms / chemically induced
-
Lung Neoplasms / prevention & control*
-
Male
-
Mice
-
Sodium-Potassium-Exchanging ATPase / drug effects
-
Sodium-Potassium-Exchanging ATPase / metabolism
Substances
-
Anticarcinogenic Agents
-
Carcinogens
-
Glycoproteins
-
Benzo(a)pyrene
-
Ca(2+) Mg(2+)-ATPase
-
Calcium-Transporting ATPases
-
Sodium-Potassium-Exchanging ATPase
-
Capsaicin