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Clin Exp Dermatol. 2008 Jul;33(4):412-4. doi: 10.1111/j.1365-2230.2007.02584.x. Epub 2008 May 21.

Type I immediate hypersensitivity reaction to cyanocobalamin but not hydroxycobalamin.

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Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland.


We report a case of a 42-year-old woman with a background of autoimmune polyglandular syndrome, who developed a type I immediate hypersensitivity reaction to intramuscular cyanocobalamin. Intradermal testing showed a positive reaction to cyanocobalamin. The patient was subsequently treated with intramuscular hydroxycobalamin after negative intradermal testing to this alternative B(12) compound. A review of previously described cases of hypersensitivity to either compound provides a rationale for the management of this rare but serious side-effect.

[Indexed for MEDLINE]

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