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Br J Surg. 2008 Jul;95(7):827-33. doi: 10.1002/bjs.6042.

Prospective matched-pair comparison of outcome after treatment for lobular and ductal breast carcinoma.

Author information

1
Department of Surgery, University College Hospital, Galway, Ireland.

Abstract

BACKGROUND:

Whether the prognosis of invasive lobular carcinoma is different from that of other invasive breast cancers is controversial. The aim of this study was to compare the outcome in age- and stage-matched patients with lobular carcinoma and those with invasive breast cancer, and in particular to compare predictors of outcome.

METHODS:

Data were obtained from a prospectively maintained database that included patients who had breast surgery for invasive cancer. Patients were matched for International Union Against Cancer stage and age at diagnosis within 5 years. Two patients with invasive ductal carcinoma were matched to each patient with invasive lobular carcinoma.

RESULTS:

There was no significant difference between invasive ductal and lobular carcinomas in terms of overall survival. Oestrogen receptor (ER)-positive invasive ductal carcinoma had a better prognosis than ER-positive invasive lobular carcinoma (P = 0.011). Similarly, ER-negative invasive ductal carcinoma was associated with worse survival than ER-negative invasive lobular carcinoma (P = 0.054).

CONCLUSION:

These results suggested that the differences in outcome between invasive ductal and lobular carcinomas may be determined by ER status.

PMID:
18498127
DOI:
10.1002/bjs.6042
[Indexed for MEDLINE]

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