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Lab Chip. 2008 Jun;8(6):892-7. doi: 10.1039/b800370j. Epub 2008 Apr 11.

Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses.

Author information

1
Department of Applied Science, University of California-Davis, 1 Shields Ave., Davis, CA 95616, USA. aeoliver@ucdavis.edu

Erratum in

  • Lab Chip. 2010 Dec 21;10(24):3427.

Abstract

Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.

PMID:
18497908
DOI:
10.1039/b800370j
[Indexed for MEDLINE]

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