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Nat Rev Cancer. 2008 Aug;8(8):604-17. doi: 10.1038/nrc2353. Epub 2008 May 22.

Integrins in angiogenesis and lymphangiogenesis.

Author information

1
Moores UCSD Cancer Center, 3,855 Health Sciences Drive, La Jolla, California 92092-0819, USA.

Abstract

Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration and survival during angiogenesis and lymphangiogenesis, whereas other integrins promote pro-angiogenic macrophage trafficking to tumours. Several integrin-targeted therapeutic agents are currently in clinical trials for cancer therapy. Here, we review the evidence implicating integrins as a family of fundamental regulators of angiogenesis and lymphangiogenesis.

PMID:
18497750
PMCID:
PMC2577722
DOI:
10.1038/nrc2353
[Indexed for MEDLINE]
Free PMC Article
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