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Novartis Found Symp. 2008;289:74-84; discussion 84-93.

Mechanisms of neuregulin action.

Author information

1
Institute of Human Nutrition and Department of Pediatrics, Columbia University Medical Center, 630 West 168th Street, New York, NY 10024, USA.

Abstract

Neuregulin 1 (Nrg1) and ErbB receptor tyrosine kinase signalling is essential for the formation and proper functioning of multiple organ systems and inappropriate Nrgl/ErbB signalling severely compromises health, contributing to such diverse pathologies as cancer and neuropsychiatric disorders. Numerous genetic modelling studies in mice demonstrate that Nrg1 signalling is important in the development of normal neuronal connectivity. Recent studies have identified novel signalling mechanisms and revealed unexpected roles of Nrg1 isoforms in both the developing and adult nervous system. Of particular interest to this discussion are findings linking deficits in Nrg1-ErbB4 signalling to perturbations of synaptic transmission, myelination, and the survival of particular sets of neurons and glia.

PMID:
18497096
PMCID:
PMC2621364
DOI:
10.1002/9780470751251.ch6
[Indexed for MEDLINE]
Free PMC Article

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