Format

Send to

Choose Destination
Am J Clin Pathol. 1991 Apr;95(4):540-6.

Identification of human papillomavirus DNA sequences in peripheral blood mononuclear cells.

Author information

1
Department of Biochemistry, Chang Gung Medical College, Taipei, Taiwan, Republic of China.

Abstract

Polymerase chain reaction (PCR) was used to amplify and identify the presence of the DNA of human papillomavirus (HPV) types 6, 11, 16, and 18 in peripheral blood mononuclear cells (PBMCs) of women with and without urogenital HPV infections. HPV DNA of various types was found in PBMCs of 13 of 25 (52.0%) patients with urogenital HPV infections and in none of the 19 control subjects who are free of urogenital HPV infections. The presence of HPV DNA in PBMCs may impair the immunologic functions of the lymphocytes and play a role in the epidemiology of HPV infections and the pathogenesis of HPV-induced diseases.

PMID:
1849701
DOI:
10.1093/ajcp/95.4.540
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center