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Am J Ther. 2008 May-Jun;15(3):198-205. doi: 10.1097/MJT.0b013e31817534d5.

A comparison of select cardiovascular outcomes by antidiabetic prescription drug classes used to treat type 2 diabetes among Military Health System beneficiaries, fiscal year 2003-2006.

Author information

1
The Office of the Assistant Secretary of Defense, Health Affairs (OASD (HA)), TRICARE Management Activity (TMA), Falls Church, VA 22043, USA.

Abstract

BACKGROUND:

Recent research suggests that there is an increased risk of cardiovascular outcomes among individuals with type 2 diabetes taking rosiglitazone (Avandia).

OBJECTIVE:

To determine if there is an increased incidence of select cardiovascular events, specifically acute myocardial infarction (AMI) and congestive heart failure (CHF), among Military Health System beneficiaries with type 2 diabetes who filled a prescription for Avandia compared with those who filled prescriptions for other antidiabetic medications.

DESIGN:

Cross-sectional analysis of data from fiscal year 2003-2006.

PARTICIPANTS:

Military Health System beneficiaries who are enrolled in TRICARE Prime [Health Maintenance Organization (HMO)-like option] with a diagnosis of type 2 diabetes.

RESULTS:

Average annual incidence of AMI and CHF was lowest among individuals who filled a prescription for biguanides (metformin) and greatest among those who filled a prescription for insulin. The incidence of AMI was highest among beneficiaries with a triple combination of antidiabetic drugs including insulin. The incidence of CHF was highest among those who took a sulfonylurea and Actos during the observation period (fiscal year 2003-2006).

LIMITATIONS:

This study has several limitations including the cross-sectional design and inability to make statistical comparisons across drug categories.

CONCLUSIONS:

There does not appear to be an increased annual incidence of AMI or CHF among TRICARE Prime beneficiaries with a diagnosis of type 2 diabetes who have filled a prescription for Avandia compared with those who filled prescriptions for other antidiabetic medications.

PMID:
18496256
DOI:
10.1097/MJT.0b013e31817534d5
[Indexed for MEDLINE]

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