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Eur J Epidemiol. 2008;23(7):491-8. doi: 10.1007/s10654-008-9261-3. Epub 2008 May 21.

Helicobacter pylori infection and Hyperemesis gravidarum. An institution-based case-control study.

Author information

1
Centre of Clinical Research, Unit of Epidemiology and Biostatistics, Ullevål University Hospital, 0407, Oslo, Norway. sair@uus.no

Abstract

BACKGROUND:

The etiology of Hyperemesis gravidarum (HG) is unclear. To test the hypothesis of an association between Helicobacter pylori infection and HG, an institution-based case-control study was performed at Aker University Hospital (AUH) during 1994-1999.

MATERIAL AND METHOD:

From the same source population, 244 incident cases of HG and 244 pregnant women free of the disease (controls) were consecutively identified.

RESULTS:

H. pylori were noted in 105 cases and 58 control subjects. The presence of H. pylori increased the risk of HG more than two fold (OR = 2.42, 95% CI: 1.64-3.57, P < 0.001). This association was much stronger in Africans as compared to non-Africans (OR = 5.26, 95% CI: 1.04-26.57 vs. OR = 1.67, 95% CI: 1.07-2.61) after controlling for the confounding effect of maternal age. A gradient effect of exposure to H. pylori, determined by presence of specific IgG antibody in serum, and increased frequency of HG was present in Africans (test for linear trend P = 0.05) and non-Africans (test for linear trend P = 0.004).

CONCLUSION:

These results indicate that H. pylori increase the risk of HG with a dose-response pattern and stronger in Africans.

PMID:
18493859
DOI:
10.1007/s10654-008-9261-3
[Indexed for MEDLINE]

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