Genes responsible for transformation by avian RNA tumor viruses

Cancer Res. 1976 Nov;36(11 Pt. 2):4282-8.

Abstract

Avian sarcoma viruses probably contain 4 genes. One of these, src, controls the process of transformation of the infected cell and has been located near the 3' end of the viral genome. The remaining 3 genes direct the synthesis of virion proteins: env (envelope proteins), pol (polymerase), and gag (internal proteins). They are probably in the order gag-poly-env-src. A scheme for the replication of these viruses is proposed, and several possible mechanisms for their origin and variability are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alpharetrovirus*
  • Animals
  • Base Sequence
  • Cell Transformation, Neoplastic*
  • Genes*
  • Genetic Code
  • Mutation
  • RNA, Viral
  • Viral Proteins / biosynthesis
  • Virus Replication

Substances

  • RNA, Viral
  • Viral Proteins