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Horm Res. 2008;70(1):22-8. doi: 10.1159/000129674. Epub 2008 May 21.

Independent effect of visceral adipose tissue on metabolic syndrome in obese adolescents.

Author information

  • 1INSERM, U690, Hôpital Robert Debré, Paris, France. cd403@dedschl.cam.ac.uk

Abstract

BACKGROUND/AIMS:

Obesity is linked to metabolic complications, even in children, but the role of the distribution of adiposity is unclear. We aimed to assess which compartment of fat mass - total (TFM), visceral (VFM) or subcutaneous (SCFM)--is related to metabolic complications in overweight and obese children and adolescents.

DESIGN:

Analyses were conducted in 159 overweight or obese children and adolescents (median body mass index 4.0 SD). TFM was measured by dual-energy x-ray absorptiometry. Distribution of abdominal fat was assessed by MRI. Insulin resistance (IR) was determined using a homeostatic model assessment. The definition of metabolic syndrome (MS) was derived from National Cholesterol Education Program ATP III.

RESULTS:

A parental history of obesity was positively and significantly associated with fat content of the three compartments (TFM: beta = 2.22; VFM: beta = 0.17; SCFM: beta = 0.12, respectively). VFM was also associated with gender (beta = -0.29) and ethnicity (beta = -0.54). TFM was a significant and independent determinant of IR (beta = 0.02) whereas IR and VFM only were significantly related to MS (OR = 3.55 and 3.66 respectively).

CONCLUSION:

Our data indicate that even in overweight children VFM was influenced by several factors such as sex and ethnicity and that a relationship was evidenced between the amount of VFM and MS.

PMID:
18493146
DOI:
10.1159/000129674
[PubMed - indexed for MEDLINE]
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