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Prostate Cancer Prostatic Dis. 2008;11(4):320-4. doi: 10.1038/pcan.2008.29. Epub 2008 May 20.

Pelvic lymphadenectomy in prostate cancer.

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  • 1Department of Urology, University of California, San Francisco, CA, USA.


This review analyzes the anatomy of the prostate gland's lymphatic drainage, the optimal anatomic extend of pelvic lymph node dissection (PLND) and which dissection may be superior, who should undergo a PLND during prostatectomy, and its potential therapeutic benefits and complications. The prostate gland's lymphatic drainage can be variable, but frequently metastatic disease is found in the internal iliac chain. We conclude that the extended PLND yields the most lymph nodes and therefore may be superior. Some have demonstrated an unproven survival benefit after performing an extended PLND, possibly from removal of occult disease or from more accurate staging.

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