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FEBS Lett. 2008 Jun 11;582(13):1802-8. doi: 10.1016/j.febslet.2008.04.061. Epub 2008 May 16.

Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury.

Author information

1
Department of Surgery, University of Missouri, Columbia, MO, USA.

Abstract

Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI.

PMID:
18486613
PMCID:
PMC2519886
DOI:
10.1016/j.febslet.2008.04.061
[Indexed for MEDLINE]
Free PMC Article

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