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Cell. 2008 May 16;133(4):581-4. doi: 10.1016/j.cell.2008.04.027.

Poised RNA polymerase II gives pause for thought.

Author information

1
Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

Abstract

Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

PMID:
18485867
DOI:
10.1016/j.cell.2008.04.027
[Indexed for MEDLINE]
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