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Vision Res. 2008 Jun;48(13):1456-70. doi: 10.1016/j.visres.2008.04.002. Epub 2008 May 16.

Possible mechanisms underlying tilt aftereffect in the primary visual cortex: a critical analysis with the aid of simple computational models.

Author information

1
Department of Electronics, Computer Science, and Systems, University of Bologna, viale Risorgimento 2, I-40136 Bologna, Italy. mauro.ursino@unibo.it <mauro.ursino@unibo.it>

Abstract

A mathematical model of orientation selectivity in a single hypercolumn of the primary visual cortex developed in a previous work [Ursino, M., & La Cara, G.-E. (2004). Comparison of different models of orientation selectivity based on distinct intracortical inhibition rules. Vision Research, 44, 1641-1658] was used to analyze the possible mechanisms underlying tilt aftereffect (TAE). Two alternative models are considered, based on a different arrangement of intracortical inhibition (an anti-phase model in which inhibition is in phase opposition with excitation, and an in-phase model in which inhibition has the same phase arrangement as excitation but wider orientation selectivity). Different combinations of parameter changes were tested to explain TAE: a threshold increase in excitatory and inhibitory cortical neurons (fatigue), a decrease in intracortical excitation, an increase or a decrease in intracortical inhibition, a decrease in thalamo-cortical synapses. All synaptic changes were calculated on the basis of Hebbian (or anti-Hebbian) rules. Results demonstrated that the in-phase model accounts for several literature results with different combinations of parameter changes requiring: (i) a depressive mechanism to neurons with preferred orientation close to the adaptation orientation (fatigue of excitatory cortical neurons, and/or depression of thalamo-cortical synapses directed to excitatory neurons, and/or depression of intracortical excitatory synapses); (ii) a facilitatory mechanism to neurons with preferred orientation far from the adaptation orientation (fatigue of inhibitory cortical neurons, and/or depression of thalamo-cortical synapses directed to inhibitory neurons, and/or depression of intracortical inhibitory synapses). By contrast, the anti-phase model appeared less suitable to explain experimental data.

PMID:
18485441
DOI:
10.1016/j.visres.2008.04.002
[Indexed for MEDLINE]
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