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Cancer Res. 2008 May 15;68(10):3566-72. doi: 10.1158/0008-5472.CAN-07-6639.

microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma.

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  • 1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia, USA.

Abstract

microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.

PMID:
18483236
DOI:
10.1158/0008-5472.CAN-07-6639
[PubMed - indexed for MEDLINE]
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