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Biochem Soc Trans. 2008 Jun;36(Pt 3):505-7. doi: 10.1042/BST0360505.

Regulation of gene expression by the RNA-binding protein Sam68 in cancer.

Author information

1
Institute of Human Genetics, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. prabs_rajan@yahoo.co.uk

Abstract

Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

PMID:
18481990
DOI:
10.1042/BST0360505
[Indexed for MEDLINE]

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