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Biochem Soc Trans. 2008 Jun;36(Pt 3):411-5. doi: 10.1042/BST0360411.

An overview of the fission yeast septation initiation network (SIN).

Author information

1
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1066 Epalinges s/Lausanne, Switzerland. andrea.krapp@epfl.ch

Abstract

The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.

PMID:
18481970
DOI:
10.1042/BST0360411
[Indexed for MEDLINE]

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