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Biochem Soc Trans. 2008 Jun;36(Pt 3):321-7. doi: 10.1042/BST0360321.

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

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1
Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), 808 Route de Lennik, B-1070, Brussels, Belgium. deizirik@ulb.ac.be

Abstract

Accumulating evidence indicates that beta-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that beta-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcription factors such as NF-kappaB (nuclear factor kappaB) and STAT-1 (signal transducer and activator of transcription 1). Understanding the regulation of these gene networks, and how they modulate beta-cell death and the 'dialogue' between beta-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a 'trial-and-error' approach to one that is really mechanistically driven.

PMID:
18481950
DOI:
10.1042/BST0360321
[Indexed for MEDLINE]
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