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Physiol Res. 2008;57 Suppl 3:S11-21. Epub 2008 May 13.

14-3-3 proteins: a family of versatile molecular regulators.

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Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.


The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.

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