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Org Biomol Chem. 2008 Jun 7;6(11):1895-7. doi: 10.1039/b804701d. Epub 2008 Apr 14.

Epigenetic remodeling of the fungal secondary metabolome.

Author information

1
Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma 73019-3032, USA. rhcichewicz@ou.edu

Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

PMID:
18480899
DOI:
10.1039/b804701d
[Indexed for MEDLINE]

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