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Bioorg Med Chem Lett. 2008 Jun 1;18(11):3242-7. doi: 10.1016/j.bmcl.2008.04.049. Epub 2008 Apr 25.

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, PO Box 2000, RY 50G-332, Rahway, NJ 07065, USA. liangqin_guo@merck.com

Abstract

Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is disclosed.

PMID:
18479920
DOI:
10.1016/j.bmcl.2008.04.049
[Indexed for MEDLINE]

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