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Biol Cell. 2008 Jun;100(6):327-42. doi: 10.1042/BC20070143.

mRNA journey to the cytoplasm: attire required.

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LEA Laboratory of Nuclear RNA metabolism, Centre de Génétique Moléculaire, CNRS - UPR2167, F-91190, Gif sur Yvette, France.


In eukaryotes, copying the genetic information from a DNA template into RNA is not sufficient itself to confer functional competence to the DNA-encoded message. mRNAs have to be processed by enzymes and packaged with proteins within nuclei to generate mRNP (messenger ribonucleoprotein) particles, before these can be exported to the cytoplasm. Processing and packaging factors are believed to interact with the nascent mRNA co-transcriptionally, which protects the highly reactive RNA molecule from a presumably aggressive nuclear environment while providing early commitment to its functional fate. In this review, we will describe the factors that are believed to provide the appropriate 'dress code' to the mRNA and the mechanisms underlying the proofreading events that guarantee its quality, focusing on yeast as a model system.

[Indexed for MEDLINE]

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