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Dement Geriatr Cogn Disord. 2008;25(6):531-8. doi: 10.1159/000132084. Epub 2008 May 14.

Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations.

Author information

1
Department of Psychiatry and Psychotherapy, Technical University Munich, Munich, Germany. robert.perneczky@lrz.tum.de

Abstract

AIMS:

To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH).

METHODS:

Fourteen patients with DLB and VH, 7 with DLB without VH and 16 healthy controls underwent clinical and (18)F-FDG PET evaluations. The 2 patient groups did not significantly differ in their clinical characteristics, except in the occurrence of VH. A voxel-wise comparison of (18)F-FDG PET scans was conducted between each of the 2 patient groups and the control group, and the patient groups among each other.

RESULTS:

Compared with the control group, hypometabolic regions were more extensive and confluent in the patient group with VH than in the group without VH. The direct comparison between the 2 patient groups revealed a significant metabolic deficit in the group with VH at the right occipito-temporal junction and the right middle frontal gyrus.

CONCLUSIONS:

These results suggest that hypometabolism in visual association areas rather than the primary visual cortex is involved in VH in DLB.

PMID:
18477846
DOI:
10.1159/000132084
[Indexed for MEDLINE]

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