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Dev Cell. 2008 May;14(5):642-4. doi: 10.1016/j.devcel.2008.04.012.

Glucose restriction: longevity SIRTainly, but without building muscle?

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP F-67404 Illkirch, France.

Abstract

The two metabolic sensors AMPK and SIRT1 take center stage as Fulco et al. reveal, in this issue of Developmental Cell, the signaling mechanism by which low glucose prevents the correct development of the myogenic program. These observations may hold some therapeutic promise against muscle wasting.

PMID:
18477447
DOI:
10.1016/j.devcel.2008.04.012
[Indexed for MEDLINE]
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